10-Hydroxycamptothecin Introduction10-Hydroxycamptothecin, the derivative of camptothecin, is a minor alkaloid isolated ... At present, as an alkaloid anticancer, It is the only known natural DNA Topo isomerase inhibitors.Formula: ... melanoma, small-cell lung cancer and leukemia.Side effects: The major side effects of hydroxycamptothecin are potentially severe diarrhea, nausea, lowered leukocyte (white ...