... all tested tumour cell cultures. Furthermore, betulin altered tumour cells morphology, decreased their motility and induced apoptotic cell death. ... betulin showed anticancer activity on human lung cancer A549 cells by inducing apoptosis and changes in protein expression profiles ... (, , ) and malignant brain tumors, , in human HL-60 cells, malignant head and neck squamous cell carcinoma SCC25 and SCC9 ...