Flaxseed hull EXtract Lignans SDG Leading Product of Organic Herb Inc. CAS No. :8001-26-1 Secoisolariciresinol Diglycoside (  

DESCRIPTION                                                     

Secoisolariciresinol diglycoside, or SDG, is a plant lignan most notably found in flaxseed (linseed). SDG is classified as a phytoestrogen since it is a plant-derived, nonsteroid compound that possesses estrogen-like activity. SDG has weak estrogenic activity. The level of SDG in flaxseed typically varies between 0.6% and 1.8%.

Lignans are one of the two major classes of phytoestrogens; the other class is the isoflavones. Plant lignans are polyphenolic substances derived from phenylalanine via dimerization of substituted cinnamic alcohols. Mammalian lignans are lignans derived from plant lignans. For example, following ingestion, SDG is converted to the aglycone secoisolariciresinol, which is then metabolized to the mammalian lignans enterolactone and enterodiol. Most of the effects of oral SDG are mediated by enterolactone and enterodiol.

The molecular formula of SDG is C32H46O16, and its molecular weight is 686.71 daltons. The aglycone of SDG is also known as 2, 3-bis (3-methoxy-4-hydroxybenzyl) butane-1, 4-diol. Enterolactone is also known as trans-2, 3-bis [(3-hydroxylphenyl) methyl]-butyrolactone. It is represented by the following structural formula: 

ACTIONS

SDG has estrogenic and antioxidant activities. It may also have antiestrogenic, anticarcinogenic, antiatherogenic and antidiabetic activities.

SDG has estrogenic and antioxidant activities. It may also have antiestrogenic, anticarcinogenic, antiatherogenic and antidiabetic activities. Research suggests lignans may benefit consumers in the following areas:

Prostate health Bone health Breast health Reducing symptoms of menopause Heart health Hair loss Acne Inflammation Potential anticancer role

Metabolism and mechanism of lignans

Lignans are natural compounds with two or three molecules of benzene propyls combination by various modalities. Being phytoestrogen, flax lignans can bind to estrogen receptors and interfere hormone metabolism as soya isoflavones and red clover isoflavones. The main ingredient of flax lignans is secoisolariciresinol diglucoside (so called SDG), SDG is the precursor of mammal lignans because it is converted into enterolactone (EL) and enterodiol (ED) after ingestion because of hydrolyzed and participation of enzyme as well as colonic bacteria. Dietary flaxseed obviously increases EL and ED concentrations in plasma up to 200 and 48 times respectively. The metabolism and mechanism is as follows:

Secoisolariciresinol Diglucoside (SDG)

ColonicaBacteria

Enterodiol (ED)

ColonicaBacteria

Enterolactone (EL)

 

Have you ever tested the SDG content of your Flaxseed Lignan products?

There are non companies have used their own in-house methods for measuring the SDG content in their Flaxseed Lignans products, so having a standard method of measurement will ensure the accuracy and safety of products for consumers becoming very important and urgently .

 

Organic Herb Inc. has established its HPLC test method of SDG in Flaxseed Lignans products at very accurate base and easy to process.

Organic Herb Inc's test method is free to get upon your request by e-mail and we are planning to get full AOAC International validation in order to set the testing as a standard method.

HPLC Chromatogram Of SDG:

 

Why Organic Herb Inc. SGD:

A.) Organic Herb Inc. SGD is 100% extracted from natural plant, very safe and more bioactive. B.) Organic Herb Inc. has the most purity SGD, Our SGD is tested by HPLC.  C.) Organic Herb Inc. SGD almost has no unpleasant taste compare to other SGD and it can be easier to take by oral. D.) Organic Herb Inc. offer SGD at a very lower price with a very high and uniform quality. E.) Organic Herb Inc. SDG has no pesticide residue. F.) More important --- we have a very large output to meet our customers' big and continual orders.

If you have any further questions or need a sample ,please do not hesitate to contact with me.

Wish you all of the best and regards!Sincerely yours,

                         

Ms.Lucy FuSales ManagerOrganic Herb Inc.Phone:+86-731-82967870Mobile:+86-159-73162721

+86-137-39075795

Fax:+86 -731 -82967861 

Flax Lignans Flaxseed Hull extract