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In fluidized bed reactors, cells are "immobilized" in small particles which move with the fluid. The small particles create a large surface area for cells to stick to and enable a high rate of transfer of oxygen and nutrients to the cells.
The fluidized bed reactor is most suitable when a high viscosity substrate solution and a gaseous substrate or product are used in a continuous reaction system. The figure below illustrates a continuous fluidized bed reactor:
fluidized bed bioreactor
In this system, care must be taken to avoid the destruction and decomposition of immobilized enzymes. The particle size of immobilized enzymes is an important factor for the formation of a smooth fluidized bed