Carmustine (CAS 154-93-8). An alkylating agent in chemotherapy and used in the treatment of several types of brain cancer.

Carmustine

Systematic (IUPAC) name: N,N'-bis(2-chloroethyl)-N-nitroso-urea

Identifiers CAS number: 154-93-8 ATC code: L01AD01 PubChem: CID 2578 DrugBank: APRD00006 ChemSpider: 2480UNII: U68WG3173YKEGG: D00254ChEMBL: CHEMBL513

Chemical data Formula: C5H9Cl2N3O2  Mol. mass: 214.049 g/mol  Pharmacokinetic data Bioavailability: 5 to 28% (oral) Protein binding: 80%

ApplicationsCarmustine is an alkylating agent in chemotherapy.  It is used in the treatment of several types of brain cancer (including glioma, glioblastoma multiforme, medulloblastoma and astrocytoma), multiple myeloma and lymphoma (Hodgkin's and non-Hodgkin).

Carmustine