Alachlor 92%/ 95%TC and 48%EC Best quality/price/service Professional package FAO Standards

NOMENCLATURE Common name: alachlor

Classification: herbicide

IUPAC name: 2-chloro-2',6'-diethyl-N-methoxymethylacetanilide

  Chemical name :2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)acetamide

  CAS RN [15972-60-8] 

PHYSICAL CHEMISTRY Composition ³93% pure.  Mol. wt. 269.8  M.f. C14H20ClNO2  Form Yellow white to wine red, odourless solid (room temperature); yellow to red liquid (>40 °C).  M.p. 40.5-41.5 ºC  B.p. 100 °C/0.0026 kPa  V.p. 2.0 mPa (25 ºC)  KOW logP = 3.09  Henry 3.2 ´ 10-3 Pa m3 mol-1 (calc.)  S.g./density 1.1330 (25 °C)  Solubility In water 170.31 mg/l (pH 7, 20 ºC). Soluble in diethyl ether, acetone, benzene, chloroform, ethanol, and ethyl acetate. Slightly soluble in heptane.  Stability Hydrolysed by strong acids and alkalis. Stable to u.v. light. Decomposes at 105 ºC.  F.p. 137 °C (closed cup); 160 °C (open cup) 

APPLICATIONS Biochemistry Acts by inhibition of protein synthesis and root elongation. Maize tolerance is attributed to rapid detoxification by glutathione transferases.  Mode of action Selective systemic herbicide, absorbed principally by germinating shoots, but also by the roots, with translocation throughout the plant, and accumulation mainly in vegetative parts rather than in reproductive parts.  Uses Used pre-emergence at 1.68-4.48 kg/ha to control annual grasses and many broad-leaved weeds in cotton, brassicas, maize, oilseed rape, peanuts, radish, soya beans and sugar cane.  Formulation types EC; GR; ME; WG. 

MAMMALIAN TOXICOLOGY Oral Acute oral LD50 for rats 930-1350 mg/kg.  Skin and eye Acute percutaneous LD50 for rabbits 13 300 mg/kg. Non-irritating to skin or eyes (rabbits). Contact sensitisation reactions observed in guinea pigs.  Inhalation LC50 (4 h) for rats 1.04 mg/l air.  NOEL (2 y) for rats £2.5 mg/kg b.w. daily; (1 y) for dogs £1 mg/kg b.w. daily. In 90 d feeding trials, rats and dogs receiving 200 mg/kg diet showed no ill-effects.  Water GV 20 mg/l (based on incidence of cancer in animals).  Other Oncogenic in rats but not in mice.  Toxicity class WHO (a.i.) Ia; EPA (formulation) III  EC hazard R40| Xn; R22| R43 

ECOTOXICOLOGY Birds Acute oral LD50 for bobwhite quail 1536 mg/kg. LC50 (5 d) for mallard ducks and bobwhite quail >5620 mg/kg diet.  Fish LC50 (96 h) for rainbow trout 1.8, bluegill sunfish 2.8, fathead minnow 5.0, channel catfish 2.1 mg/l.  Daphnia EC50 (48 h) 10 mg/l.  Algae TL50 (72 h) for Selenastrum capricornutum 12 mg/l.  Other aquatic spp. EC50 (48 h) for crayfish >320 mg/l.  Bees Not hazardous to bees when used as directed; LD50 32 mg/bee.  Worms LC50 (14 d) for earthworms 387 mg/kg dry soil. 

ENVIRONMENTAL FATE Animals Rapidly oxidised by rat liver microsomal oxygenases to 2,6-diethylaniline (Pestic. Biochem. Physiol., 1989, 33, 16; J. Agric. Food Chem., 1989, 37, 1088; P. C. C. Feng et al., Drug Metab. Dispos., 1990, 18, 373).  Plants Rapidly metabolised in plants to 2-chloro-2',6'-diethylacetanilide, with further degradation to the aniline derivative.  Soil/Environment Rapidly degraded in soil by microbial action to 2-chloro-2',6'-diethylacetanilide, with further degradation to the aniline derivative; DT50 1-30 d. Persists in soil for c. 6-10 w (J. Tiedie et al., J. Agric. Food Chem., 1975, 23, 77; J. K. Lee, Hanguk Nanghwa Hakhoechi, 1986, 29, 182; Rev. Environm. Contam. Toxicol., 1989, 110, 110-114). In surface water, 55% degraded in 28 d. 

alachlor 48 ec in Herbicide